Intraepithelial carcinoma (Bowen disease) - Intraepitēlija Karcinoma (Bowen Slimība)
☆ 2022. gada Stiftung Warentest rezultātos no Vācijas patērētāju apmierinātība ar ModelDerm bija tikai nedaudz zemāka nekā ar maksas telemedicīnas konsultācijām.
Tipisks gadījums ― Intraepitēlija Karcinoma (Bowen Slimība) (Intraepithelial carcinoma (Bowen disease)) var tikt nepareizi diagnosticēta kā ilgstoša, neniezoša ekzēma.
References
Bowen's disease (BD) ir ādas vēža veids, kas sākas ādas ārējā slānī (epidermā) . Tas ir biežāk sastopams baltās rases iedzīvotājiem un bieži sastopams vietās, kas pakļautas saules gaismai, taču tas var parādīties arī citur. BD parasti parādās kā viens bojājums. BD bieži tiek uzskatīta par brīdinājuma zīmi, pirms attīstās nopietnāks ādas vēža veids. Lai diagnosticētu BD, ārsti parasti paļaujas uz audu paraugu pārbaudi mikroskopā (biopsija) .
Bowen's disease (BD) is an in-situ squamous cell carcinoma of epidermis. The etiology of BD is multifactorial with high incidence among Caucasians. BD is common in photo-exposed areas of skin, but other sites can also be involved. Lesions are usually solitary. The morphology of BD differs based on age of the lesion, site of origin, and the degree of keratinization. BD is considered as the lull before the storm, which precedes an overt squamous cell carcinoma. Histopathology is the gold standard diagnostic modality to confirm the diagnosis.
Bowen's disease (BD) is an in-situ squamous cell carcinoma of epidermis. The etiology of BD is multifactorial with high incidence among Caucasians. BD is common in photo-exposed areas of skin, but other sites can also be involved. Lesions are usually solitary. The morphology of BD differs based on age of the lesion, site of origin, and the degree of keratinization. BD is considered as the lull before the storm, which precedes an overt squamous cell carcinoma. Histopathology is the gold standard diagnostic modality to confirm the diagnosis.
Bowen's disease galvenokārt skar baltās personas vecumā virs 60 gadiem. Galvenie riska faktori ir ilgstoša saules iedarbība, novājināta imūnsistēma, arsēna iedarbība un ādas HPV infekcija. HPV celmi 16, 18, 34 un 48 ir saistīti ar Bovena slimību dzimumorgānu apvidos. HPV iesaistīšanās gadījumos, kas nav saistīti ar dzimumorgāniem, ir mazāk skaidra.
Bowen disease is most commonly found in white patients over 60 years old. Other risk factors include chronic sun exposure, immunosuppression, arsenic exposure and cutaneous human papillomavirus (HPV) infection. HPV types 16, 18, 34 and 48 cause Bowen disease at genital sites; the role of HPV in nongenital cases of Bowen disease is less well defined. HPV types 2, 16, 34 and 35 have been rarely identified within nongenital lesions.
Bowen disease is most commonly found in white patients over 60 years old. Other risk factors include chronic sun exposure, immunosuppression, arsenic exposure and cutaneous human papillomavirus (HPV) infection. HPV types 16, 18, 34 and 48 cause Bowen disease at genital sites; the role of HPV in nongenital cases of Bowen disease is less well defined. HPV types 2, 16, 34 and 35 have been rarely identified within nongenital lesions.
Tas parasti parādās kā eritematoza, zvīņaina vai garoza vieta jebkurā ķermeņa vietā. Visbiežāk sastopamā vieta ir apakšstilbi.
To var izārstēt ar dažādām ārstēšanas iespējām, piemēram, krioterapiju, kiretāžu, kauteriju, fotodinamisko terapiju vai bojājuma izgriešanu.
○ Diagnostika un ārstēšana
#Dermoscopy
#Skin biopsy
#Mohs surgery
#Photodynamic therapy